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. Author manuscript; available in PMC: 2015 Feb 6.
Published in final edited form as: J Lung Cancer. 2011;10(2):69–76. doi: 10.6058/jlc.2011.10.2.69

Fig. 1.

Fig. 1

Somatostatin receptor signaling cascade. SSTR activation decreases hormonal secretion in most cells by decreasing cyclic AMP and by altering voltage gated potassium and calcium channels. In a minority of cells (pancreatic B-cells), hormonal secretion is increased. SSTR signals through PTPases to alter ERK1/2 phosphorylation to impair p27kip1 degradation which leads to cell growth arrest. SSTR also signals through PTPases to induce apoptosis. Rarely SSTR2 induces proliferation. ERK: extracellular signal-regulated kinase, Gα, Gβ, Gγ: G-protein subunit, PLC: phospholi-apse C, cAMP: cyclic adenosine monophosphate, IP3: inositol tri-phosphate, PTPase: phosphotyro-sine phosphatase, SRIF: somatostatin, SHP: Src homology phosphatase, PTP-η: phosphotyrosine phosphatase η.