Table 2. Phenotype frequencies of HLA-A, HLA-B and DRB1 and their association with dengue disease severity.
| DSS and DHF vs Control | DF vs Control | DSS and DHF vs DF | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotype | DSS and DHF No. (%) | DF No. (%) a | Control No. (%) b | OR (95% CI) | P value | Pc b | OR (95% CI) | P value | Pc | OR (95% CI) | P value | Pc |
| A locus | n = 153 | n = 92 | n = 296 | |||||||||
| 02:03 | 2 (1.3) | 5 (5.4) | 3 (1.0) | 1.3 (0.2–7.8) | >0.999 | - | 5.6 (1.3–24) | 0.021 | 0.231 | 0.2 (0.04–1.2) | 0.107 | - |
| 33:01 | 3 (2.0) | 5 (5.4) | 34 (11.5) | 0.2 (0.05–0.5) | 0.0002 | 0.0022 | 0.4 (0.2–1.2) | 0.086 | - | 0.3 (0.08–1.5) | 0.156 | - |
| B locus | n = 155 | n = 93 | n = 297 | |||||||||
| 07:05 | 3 (1.9) | 4 (4.3) | 18 (6.1) | 0.3 (0.09–1.1) | 0.0439 | 0.790 | 0.7 (0.2–2.1) | 0.551 | - | 0.4 (0.1–2.0) | 0.311 | - |
| 35:01 | 23 (14.8) | 7 (7.5) | 24 (8.1) | 2.0 (1.1–3.6) | 0.03 | 0.540 | 0.9 (0.4–2.2) | 0.890 | - | 2.1 (0.9–5.2) | 0.09 | - |
| 38:02 | 34 (21.9) | 24 (25.8) | 91 (30.6) | 0.6 (0.4–1.0) | 0.0489 | 0.880 | 0.8 (0.5–1.3) | 0.378 | - | 0.8 (0.4–1.5) | 0.489 | - |
| 48:01 | 11 (7.1) | 2 (2.2) | 24 (8.1) | 0.9 (0.4–1.8) | 0.7257 | - | 0.3 (0.06–1.1) | 0.0365 | 0.657 | 3.5 (0.8–16.0) | 0.0935 | - |
| 51:01 | 16 (10.3) | 6 (6.5) | 15 (5.1) | 2.2 (1.0–4.5) | 0.0425 | 0.765 | 1.3 (0.5–3.4) | 0.595 | - | 1.7 (0.6–4.4) | 0.312 | - |
| 58:01 | 5 (3.2) | 4 (4.3) | 28 (9.4) | 0.3 (0.1–0.8) | 0.0131 | 0.236 | 0.4 (0.1–1.3) | 0.112 | - | 0.7 (0.2–2.8) | 0.667 | - |
| DRB1 locus | n = 153 | n = 90 | n = 300 | |||||||||
| 03:01 | 4 (2.6) | 2 (2.2) | 24 (8) | 0.3 (0.1–0.9) | 0.0204 | 0.286 | 0.3 (0.06–1.1) | 0.0447 | 0.626 | 1.2 (0.2–6.6) | 0.886 | - |
| 12:02 | 56 (36.6) | 27 (30) | 79 (26.3) | 1.6 (1.1–2.5) | 0.0256 | 0.358 | 1.2 (0.7–2.0) | 0.493 | - | 1.3 (0.8–2.4) | 0.299 | - |
aThe number for each HLA locus shows the number of successfully typed samples
bCorrected P-values (Pc) were only calculated for loci with P-values less than 0.05