. 2015 Feb 6;10(2):e0117008. doi: 10.1371/journal.pone.0117008

Table 1. Serum metabolic parameters and food intake.

Parameters	Chow diet (week)					HFHS diet (week)
Parameters	0	1	2	4	8	1	2	4	8
TG (mM)	1.29±0.12	1.57±0.12	1.01±0.1	1.28±0.28	1.12±0.08	1.75±0.19	2.93±0.22^**	2.41±0.25^**	1.90±0.14^**
TC (mM)	1.39±0.03	1.87±0.09	1.51±0.06	1.46±0.07	1.59±0.04	2.50±0.13^**	3.31±0.13^**	3.34±0.16^**	2.95±0.13^**
HDL-c (mM)	1.11±0.03	1.02±0.02	1.00±0.03	1.01±0.02	1.02±0.01	0.88±0.02	0.69±0.04^**	0.72±0.02^**	0.80±0.04^**
LDL-c (mM)	0.19±0.01	0.41±0.03 ^§	0.25±0.13	0.28±0.01	0.32±0.01	0.95±0.10^**	1.37±0.06^**	1.68±0.04 ^† ^**	1.60±0.08 ^† ^**
FFA (u/l)	1787±97.8	1750±60.5	1746±207.4	1743±57.1	1792±81.6	1766±57.2	1925±77.8	2061±199	2414±145^**
Leptin (ng/ml)	0.73±0.07	0.65±0.06	1.55±0.10 ^§	1.61±0.23 ^§	1.69±0.09 ^§	0.70±0.08	3.44±0.51 ^† ^**	3.19±0.51 ^† ^**	3.43±0.73 ^† ^**
Food intake (kal/d)	34.1±1.9	38.9±1.9	44.0±1.9	46.6±2.2	73.5±3.1 ^§	42.1±2.1	52.2±2.4	61.6±3.1	102.2±3.8^**
Insulin (IU/L)	31.9±1.94	45.5±2.06	37.8±4.51	34.3±1.92	36.7±1.27	139.6±9.4^**	177.6±19.54^**	248.2±15.58 ^† ^**	194.5±25.47 ^† ^**
Glucose (mM)	4.3±0.18	6.1±0.47	4.6±0.25	4.8±0. 21	5.0±0.11	9.2±0.31^**	9.3±0.29^**	9.2±0.23^**	8.8±0.26^**
HOMA-IR	6.1±0.55	7.1±0.65	7.6±0.86	7.4±0.68	8.1±0.34	55.5±3.46^**	74.5±10.50^**	101.3±5.31 ^† ^**	77.7±15.69 ^† ^**
OGTT-AUC	14.28±0.28	14.89±0.29	ND	ND	ND	14.48±0.26	14.69±0.28	15.48±0.61 ^§	15.12±0.48 ^§

Blood was drawn after 12 h fasting. Values are means ± SE (n = 6–8 per group).

^§ P<0.05 relative to 0-week under chow diet,

^† P <0.05 relative to 1-week under HFHS diet;

^** P<0.01, HFHS diet versus chow diet. TG, triglyceride; TC, total cholesterol; HDL-c, high-density lipoprotein associated cholesterol; LDL-c, low density lipoprotein associated cholesterol; FFA, free fatty acid; HOMA-IR, homeostasis model assessment of basal insulin resistance; OGTT, area under curve of oral glucose tolerance test; ND, Not determined.