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. 2015 Feb 6;10(2):e0117412. doi: 10.1371/journal.pone.0117412

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© 2015 Dametto et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A) ZyFISH results. Examples of nuclei which show either one (FTgpi155+/-) or two bright fluorescent signals (FTgpi155^+/+), indicative of heterozygosity or homozygosity for the transgene. (B) Survival curves of mice expressing FTgpi in the absence (x Prnp ^o/o) or presence (x Prnp ^+/+) of full-length PrP. The number of mice is indicated in the legend. Higher expressor FTgpi155 Prnp ^+/+ and FTgpi155 Prnp ^o/o mice died significantly earlier than FTgpi177 Prnp ^+/+ (p<0.0001) and FTgpi177 Prnp ^o/o (p<0.0001) mice respectively, suggesting that toxicity is dose-dependent. FTgpi177 Prnp ^+/+ mice died significantly earlier than FTgpi177 Prnp ^o/o mice (p<0.001), indicating that PrP^C may exacerbate the phenotype. Statistics: Log-Rank (Mantel-Cox) test. (C) Typical clinical phenotypes at terminal stage. Left panel: FTgpi155^+/+ mouse showing ataxia symptoms. Central and right panel: representation of a grid test. FTgpi155^+/+ legs repeatedly falling through the grid.