Skip to main content
. 2015 Feb 6;10(2):e0117412. doi: 10.1371/journal.pone.0117412

Fig 7. FTgpi induces ER stress in vivo.

Fig 7

(A) mRNA was extracted from cerebella of FTgpi155 and Prnp o/o mice. mRNA levels of ER stress markers were quantified by RT-PCR. XBP1, BiP and CHOP were found to be significantly upregulated. *P<0.05 and **P<0.01 by unpaired two-tails t-test. (B) Cerebellum homogenates of FTgpi177 and Prnp o/o mice were analyzed by Western blot. p-PERK was increased in cerebellum of FTgpi177 mice. Blot was first decorated with p-PERK antibody, stripped for 20 min, and stained with PERK. Each bar indicates the mean ±SEM of 3 biological replicates. *** P<0.001 by unpaired two-tails t-test (each bar is compared to BL6).