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. 2015 Feb 6;10(2):e0117405. doi: 10.1371/journal.pone.0117405

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© 2015 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A,B) Cell morphology of CAFs (passage 25) and NFs (passage 13). The CAFs did not show significant morphological changes compared with the NFs before passage 25; however, the NFs showed changes in morphology, including an enlarged and more flattened outline, compared with the CAFs after passage 10. (C) Cell morphology of primary cultured mouse skin epithelia at passage 1. (D) The mouse skin epithelia showed positive staining of pan-CK (positive control). (E–L) The CAFs and NFs showed negative staining of pan-CK and positive staining of vimentin, indicating their fibroblast identities. Compared with the NFs, the CAFs showed positive staining of α-SMA and Fap, two markers of activated fibroblasts.