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. 2015 Feb 6;10(2):e0117405. doi: 10.1371/journal.pone.0117405

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© 2015 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 6 — (A,B) Protein levels of α-SMA and Fap in NFs after being co-cultured with HEp-2 cells for 7 d. The NFs and CAFs served as controls. The HEp-2 co-cultured NFs did not show elevated expressions of α-SMA and Fap. (C) Tumor nodules induced by CAFs and NFs (both mixed with HEp-2 cells) in nude mice. (D) Pathological examination revealed that all tumor nodules were typical laryngeal squamous cell carcinoma, and the tumor cells were surrounded by numerous CAFs. (E) Statistical analysis of tumor weights (**p<0.01).