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. 2015 Feb 6;10(2):e0115995. doi: 10.1371/journal.pone.0115995

Fig 5. Autoinhibition states of h-importin-α1 by IBB binding and homodimerization.

Fig 5

(A) A conventional scheme of autoinhibition by self-binding of IBB domain. The IBB domain bound in the NLS binding sites autoinhibits NLS binding. In addition, the current work reveals the IBB domain also prevents it from homodimerization. In turn, the bound IBB domain dissociates from the NLS binding sites by binding of NLS peptides and/or importin-β. (B) A potential homodimer autoinhibition mode. The current study reveals that a novel autoinhibition state by homodimerization, which possibly corresponds to NLS binding regulation.