Table 2. Association of the 55 polymorphisms studied with aggression levels.
SNP | Gene | Aggression (total score) | p # | |||
---|---|---|---|---|---|---|
MM | Mm | mm | ||||
1. | rs1048101 | ADRA1A | 66.66 | 66.50 | 66.46 | 0.9684 |
2. | rs3808585 | ADRA1A | 66.15 | 68.19 | 65.93 | 0.2294 |
3. | rs2236554 | ADRA1D | 65.31 | 67.18 | 68.29 | 0.0840 |
4. | rs553668 | ADRA2A | 66.52 | 66.61 | 70.47 | 0.8682 |
5. | rs11030104 | BDNF | 66.56 | 66.60 | 67.73 | 0.8735 |
6. | rs2049045 | BDNF | 66.34 | 67.15 | 66.73 | 0.5703 |
7. | rs6265 | BDNF | 66.94 | 66.80 | 65.98 | 0.9220 |
8. | rs7103411 | BDNF | 66.55 | 66.53 | 67.34 | 0.9163 |
9. | rs7094179 | CDNF | 65.81 | 66.46 | 68.32 | 0.6485 |
10. | rs7900873 | CDNF | 67.03 | 66.49 | 64.68 | 0.3912 |
11. | rs1051730 | CHRNA3 | 67.53 | 65.51 | 66.58 | 0.1190 |
12. | rs16969968 | CHRNA5 | 67.45 | 65.77 | 66.61 | 0.2138 |
13. | rs4680 | COMT | 67.07 | 66.58 | 67.62 | 0.8569 |
14. | rs135745 | CSNK1E | 65.99 | 66.63 | 66.24 | 0.7121 |
15. | rs1997644 | CSNK1E | 66.83 | 66.31 | 65.68 | 0.7781 |
16. | rs1611115 | DBH | 65.74 | 67.36 | 70.89 | 0.0941 |
17. | rs6271 | DBH | 66.59 | 66.68 | 61.00 | 0.8731 |
18. | rs4532 | DRD1 | 66.55 | 65.94 | 67.91 | 0.9000 |
19. | rs6277 | DRD2 | 66.81 | 67.06 | 66.39 | 0.9148 |
20. | rs1800497 | DRD2 | 66.72 | 67.70 | 61.29 | 0.7106 |
21. | rs1079597 | DRD2 | 67.20 | 66.38 | 57.95 | 0.4397 |
22. | rs1800498 | DRD2 | 67.07 | 66.46 | 67.34 | 0.7979 |
23. | rs2134655 | DRD3 | 65.71 | 67.81 | 66.12 | 0.1250 |
24. | rs3732790 | DRD3 | 67.03 | 66.42 | 65.90 | 0.5267 |
25. | rs6280 | DRD3 | 66.98 | 66.60 | 64.46 | 0.4667 |
26. | rs963468 | DRD3 | 67.25 | 67.01 | 65.06 | 0.5779 |
27. | rs11246226 | DRD4 | 67.31 | 66.33 | 66.41 | 0.4831 |
28. | rs3758653 | DRD4 | 66.51 | 66.48 | 69.93 | 0.9091 |
29. | rs916455 | DRD4 | 66.93 | 62.82 | 46.67 | 0.0275 |
30. | rs936460 | DRD4 | 66.60 | 66.39 | 67.70 | 0.9890 |
31. | rs3733829 | EGLN2 | 66.96 | 66.76 | 65.38 | 0.6238 |
32. | rs222843 | GABARAP | 66.50 | 66.09 | 68.77 | 0.9562 |
33. | rs11111 | GDNF | 66.56 | 65.90 | 73.85 | 0.9972 |
34. | rs1549250 | GDNF | 66.75 | 65.38 | 70.34 | 0.8604 |
35. | rs1981844 | GDNF | 66.48 | 66.85 | 72.22 | 0.4727 |
36. | rs2910702 | GDNF | 66.27 | 66.40 | 68.79 | 0.5293 |
37. | rs2973041 | GDNF | 66.68 | 66.24 | 71.95 | 0.9268 |
38. | rs2973050 | GDNF | 66.30 | 66.49 | 68.89 | 0.5259 |
39. | rs3096140 | GDNF | 65.79 | 66.97 | 68.52 | 0.1457 |
40. | rs3812047 | GDNF | 66.45 | 67.46 | 70.87 | 0.3422 |
41. | rs6925 | HTR1A | 66.55 | 67.63 | 65.63 | 0.9441 |
42. | rs1228814 | HTR1B | 67.20 | 66.47 | 63.95 | 0.5336 |
43. | rs130058 | HTR1B | 67.22 | 65.55 | 70.74 | 0.3419 |
44. | rs13212041 | HTR1B | 67.09 | 66.21 | 66.87 | 0.5259 |
45. | rs11568817 | HTR1B | 68.70 | 65.76 | 67.12 | 0.0605 |
46. | rs6296 | HTR1B | 66.21 | 67.33 | 68.60 | 0.2601 |
47. | rs6311 | HTR2A | 66.78 | 66.32 | 67.41 | 0.9130 |
48. | rs6313 | HTR2A | 66.44 | 66.09 | 67.44 | 0.9969 |
49. | rs6314 | HTR2A | 67.02 | 63.98 | 73.67 | 0.0765 |
50. | rs7322347 | HTR2A | 69.21 | 64.92 | 66.35 | 0.0007* |
51. | rs7984966 | HTR2A | 67.45 | 65.65 | 65.58 | 0.1356 |
52. | rs3813929 | HTR2C | 67.01 | 63.67 | 66.43 | 0.2163 |
53. | rs518147 | HTR2C | 66.73 | 66.44 | 67.18 | 0.3203 |
54. | rs6318 | HTR2C | 66.43 | 66.46 | 67.63 | 0.2277 |
55. | rs907094 | PPP1R1B | 67.04 | 65.18 | 68.84 | 0.2994 |
Nominally significant associations are indicated by bold, italics.
* Significant after Bonferroni correction
# Dominant model (MM vs. Mm and mm).