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. 2015 Feb 6;10(2):e0117097. doi: 10.1371/journal.pone.0117097

Figure 4. β-catenin knockdown reduces the in vivo tumorigenic potential of HCC38 TNBC cells.

Figure 4

(A) 5x10^6 parental, scrambled control shRNA or β-catenin-knockdown cells were injected with matrigel into the mammary fat pad of Nu/Nu female mice (n = 10 per group) and were sacrificed 11 weeks later. Dot plot of tumor volume for tumor-bearing mice is shown with mean per group demarcated by the line. p<0.04 between β-catenin-knockdown and control cells by ANOVA. (B) Tumor growth over 11 weeks after implantation and biweekly measurements. p<0.05 between β-catenin-knockdown and control cells by ANOVA. (C) Histopathology of tumors from mice injected with β-catenin-knockdown and control. Tumors were fixed, sectioned and stained with H&E. Magnification, 10X.