Table 3. Stratification analysis of the miRNA polymorphisms.
Characteristics | rs2910164 | rs11614913 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Control* | Case* | ORadd (95% CI) | P add † | P interaction | Control* | Case* | ORadd (95% CI) | P add † | P interaction | |
Age | ||||||||||
< = 60 | 112/121/30 | 84/107/35 | 1.30 (0.95–1.76) | 0.097 | 70/128/65 | 69/112/45 | 0.91 (0.68–1.22) | 0.528 | ||
>60 | 107/136/25 | 105/154/46 | 1.40 (1.06–1.86) | 0.020 | 0.628 | 83/138/47 | 97/153/55 | 0.96 (0.74–1.26) | 0.789 | 0.564 |
Sex | ||||||||||
Male | 133/168/26 | 131/160/36 | 1.17 (0.89–1.54) | 0.267 | 96/155/76 | 96/170/61 | 0.89 (0.69–1.13) | 0.338 | ||
Female | 86/89/29 | 58/101/45 | 1.65 (1.21–2.26) | 0.002 | 0.122 | 57/111/36 | 70/95/39 | 0.95 (0.69–1.30) | 0.756 | 0.773 |
Smoking | ||||||||||
No | 150/183/45 | 123/183/56 | 1.29 (1.00–1.66) | 0.048 | 111/191/76 | 107/185/70 | 1.02 (0.80–1.31) | 0.848 | ||
Yes | 69/74/10 | 66/78/25 | 1.56 (1.08–2.26) | 0.018 | 0.323 | 42/75/36 | 59/80/30 | 0.75 (0.54–1.05) | 0.093 | 0.133 |
Drinking | ||||||||||
No | 182/203/46 | 145/216/69 | 1.44 (1.15–1.82) | 0.002 | 123/223/85 | 139/213/78 | 0.88 (0.70–1.10) | 0.235 | ||
Yes | 37/54/9 | 44/45/12 | 1.08 (0.67–1.74) | 0.753 | 0.206 | 30/43/27 | 27/52/22 | 1.06 (0.69–1.62) | 0.802 | 0.479 |
Hypertension | ||||||||||
No | 172/197/47 | 68/91/32 | 1.34 (1.03–1.74) | 0.029 | 124/206/86 | 58/93/40 | 1.01 (0.78–1.30) | 0.952 | ||
Yes | 47/60/8 | 121/170/49 | 1.38 (0.98–1.93) | 0.062 | 0.814 | 29/60/26 | 108/172/60 | 0.77 (0.56–1.05) | 0.099 | 0.233 |
Diabetes mellitus | ||||||||||
No | 194/238/53 | 138/194/65 | 1.30 (1.04–1.62) | 0.019 | 142/238/105 | 124/198/75 | 0.91 (0.74–1.13) | 0.393 | ||
Yes | 25/19/2 | 51/67/16 | 1.78 (0.97–3.25) | 0.063 | 0.296 | 11/28/7 | 42/67/25 | 0.92 (0.54–1.58) | 0.766 | 0.974 |
*Wild-type homozygote/heterozygote/variant homozygote.
†Additive model (wild-type homozygote vs. heterozygote vs. variant homozygote). Data were calculated by unconditional logistic regression, adjusted for age, sex, smoking, drinking, BMI, hypertension and diabetes mellitus.