Skip to main content
. Author manuscript; available in PMC: 2015 Aug 5.
Published in final edited form as: Nature. 2014 Dec 10;518(7537):102–106. doi: 10.1038/nature13917

Figure 1. Overall design for the Early-Onset Myocardial Infarction Study within the U.S. National Heart, Lung, and Blood Institute’s Exome Sequencing Project.

Figure 1

Whole exome sequencing was performed in 1,973 individuals from the phenotypic extremes. To test the hypothesis that low-frequency variants confer risk for myocardial infarction (MI), we performed follow-up statistical imputation and array-based genotyping of single nucleotide variants. To test the hypothesis that a burden of rare mutations in a gene confers risk for MI, we performed targeted re-sequencing and additional exome sequencing.