Table 3.
Multivariable Analysis of Progression-Free Survival
| Clinical Variable | Hazard Ratio | 95% Confidence Interval | p-value | |
|---|---|---|---|---|
| Platinum Refractory | 1.11 | 0.83 | 1.49 | 0.49 |
| Age ≥ 65 | 1.07 | 0.80 | 1.43 | 0.63 |
| Performance Status = 1 | 1.33 | 0.99 | 1.77 | 0.06 |
| Current Smoker vs. Former or Never | 0.90 | 0.67 | 1.22 | 0.51 |
| Male Sex | 1.14 | 0.87 | 1.51 | 0.35 |
| Elevated LDH | 1.83 | 1.37 | 2.43 | <.0001 |
| 2 or more prior chem regimens vs. only 1 | 0.87 | 0.51 | 1.47 | 0.59 |
| Weight Loss ≥ 5% | 1.09 | 0.80 | 1.48 | 0.59 |
| Prior radiation therapy | 1.22 | 0.87 | 1.70 | 0.26 |
| S0802 vs. (S0435 or S0327) | 1.82 | 1.29 | 2.55 | 0.001 |