Table 1. Dose escalation scheme.
| Dose level | Bortezomib mg/m2 | Paclitaxel mg/m2 | Carboplatin AUC |
|---|---|---|---|
| -1 | 0.5 | 120 | 5 |
| 0 | 0.5 | 135 | 5 |
| **1 | 0.5 | 150 | 5 |
| 2 | 0.8 | 150 | 5 |
| 3 | 1.0 | 150 | 5 |
| 4 | 1.0 | 175 | 5 |
| 5 | 1.0 | 175 | 6 |
| 6 | 1.2 | 175 | 6 |
Starting dose level
| Dose level | Bortezomib mg/m2 | Paclitaxel mg/m2 | Carboplatin AUC |
|---|---|---|---|
| -1 | 0.5 | 120 | 5 |
| 0 | 0.5 | 135 | 5 |
| **1 | 0.5 | 150 | 5 |
| 2 | 0.8 | 150 | 5 |
| 3 | 1.0 | 150 | 5 |
| 4 | 1.0 | 175 | 5 |
| 5 | 1.0 | 175 | 6 |
| 6 | 1.2 | 175 | 6 |
Starting dose level