Table 2.

Brain areas that showed significant activation during the solving of addition and subtraction problems in the combined group of DD and TD children

Peak z-score	Cluster size (voxels)	Peak z-score	Peak MNI coordinates
			x	y	Z
Addition & Subtraction
Bilateral visual cortex/lingual gyrus/ cerebellum	9467	7.59	16	−84	4
Pre-SMA	2742	7.43	−4	10	52
Left precentral/ postcentral gyrus	2876	6.65	−36	−26	54
Left insula	694	6.61	−30	24	6
Right insula	592	5.59	36	20	4
Left IPS	677	5.31	−28	−64	42
Left thalamus	286	5.21	−12	−20	12
Right IPS	263	4.93	32	−60	44
Left MFG	97	4.65	−50	30	34
Right MFG	271	4.51	48	38	26

DD = Developmental Dyscalculia, TD = Typically Developing, SMA = Supplementary Motor Area, IPS = IntraParietal Sulcus, MFG = Middle Frontal Gyrus. Regions significant at height threshold of p < .001, corrected for multiple spatial comparisons at p < .01. Voxel size is 2 mm³.