Table 5.
Single and cross-compartment HIV-1 Env-reactive clonal B cell lineages isolated from blood (BLD) and colostrum (CLM).
| Clonal Lineagea | Compartment (Number of mAbs) | Env Specificity (Number of mAbs) | Ig Isotype | VH | VK or VL |
|---|---|---|---|---|---|
| CH9105 | |||||
| DH279, DH280 | CLM (2) | gp120 (2) | IgG1 | 1~69 | 1~12 |
| DH281, DH282 | CLM (2) | gp41 (2) | IgG1 | 1~2 | 1~12 |
| DH276, DH277, DH278 | CLM (2)/BLD (1) | gp120 (3) | IgG1 | 1~69 | 3~20 |
| CH9208 | |||||
| DH283, DH284 | CLM (2) | gp120 (2) | IgG1 | 3~49 | 3~20 |
| DH285, DH286, DH287 | CLM (3) | gp120 (3) | IgG1 | 1~69 | 3~20 |
| CH0404 | |||||
| DH288, DH289 | CLM (2) | gp41 (2) | IgG1 | 1~69 | 3~11 |
a
The clonal lineages are named by their member antibody numbers.