Table 3. Results of subgroup analysis and sensitivity analysis.
| Study | No | Sensitivity | I 2 | Specificity | I 2 | PLR | NLR | AUC |
|---|---|---|---|---|---|---|---|---|
| Well differentiated HCC | ||||||||
| Overall | 8 | 0.54(0.47–0.61) | 89% | 0.90(0.87–0.93) | 43.6% | 4.88(2.99–7.97) | 0.46(0.27–0.77) | 0.9311 |
| Subgroup analysis | ||||||||
| VA | 5 | 0.40(0.31–0.49) | 87.8% | 0.93(0.89–0.95) | 1.2% | 3.98(1.53–10.35) | 0.63(0.40–1.00) | 0.9705 |
| ADC-Q | 3 | 0.75(0.64–0.83) | 53.5% | 0.86(0.80–0.90) | 0.3% | 5.36(3.69–7.79) | 0.28(0.16–0.50) | 0.9035 |
| Sensitivity analysis | ||||||||
| Overall | 6 | 0.68(0.60–0.76) | 62.8% | 0.90(0.87–0.93) | 58.1% | 6.35(4.08–9.88) | 0.36(0.23–0.57) | 0.9101 |
| VA | 3 | 0.60(0.48–0.72) | 63.5% | 0.94(0.89–0.96) | 36.8% | 6.96(2.45–19.76) | 0.46(0.24–0.85) | 0.9618 |
| Poorly differentiated HCC | ||||||||
| Overall | 9 | 0.84(0.78–0.89) | 38.7% | 0.48(0.43–0.52) | 96.4% | 2.29(1.43–3.69) | 0.30(0.22–0.41) | 0.8513 |
| Subgroup analysis | ||||||||
| VA | 4 | 0.91(0.83–0.96) | 40.2% | 0.25(0.20–0.30) | 84.5% | 1.25(1.08–1.45) | 0.37(0.19–0.72) | 0.6316 |
| ADC-Q | 5 | 0.78(0.69–0.85) | 0.0% | 0.82(0.77–0.87) | 52.2% | 4.10(2.55–6.58) | 0.28(0.20–0.40) | 0.7822 |
| Sensitivity analysis | ||||||||
| Overall | 7 | 0.83(0.76–0.89) | 53.2% | 0.54(0.49–0.59) | 96.7% | 2.98(1.15–7.70) | 0.28(0.20–0.39) | 0.8630 |
| VA | 2 | 0.98(0.87–1.00) | 0.0% | 0.22(0.17–0.29) | 89.1% | 1.35(0.96–1.88) | 0.16(0.03–0.77) | / |
VA, visual assessment; ADC-Q, ADC quantification; No, number of data sets; I2, corresponding inconsistency index (I2) of the pooled sensitivity and specificity; PLR, positive likelihood ratio; NLR, negative likelihood ratio; AUC, areas under the SROC curve. Numbers in parentheses are 95% confidence intervals.