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. 2015 Feb 6;10(2):e0117150. doi: 10.1371/journal.pone.0117150

Table 1. The Pharmaceutical Value Chain [17].

Early Stage Discovery Late Stage Discovery Clinical Trials Regulatory Approval
Description Basic research (i.e., undirected research into the mechanisms that cause disease) and target identification and validation (i.e., identifying and validating points where drugs can intervene to disrupt disease) Finding and optimizing lead compounds to ensure that they possess the properties needed to make an effective drug. Determining the efficacy and safety of a drug/vaccine in people Securing governmental authorization to sell a drug/vaccine