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. 2015 Feb 6;10(2):e0117684. doi: 10.1371/journal.pone.0117684

Table 3. Suggestive SNP-SNP interactions—secondary analysis.

SNPA ChrA Gene MAF SNPA Pvalue SNPB ChrB Gene MAF SNPB Pvalue Int. Pvalue BHF-FHS Int. PvalueMIGen
rs9840469 3 FRMD4B 0.38 7.00x10-4 rs10911935 1 PLA2G4A 0.21 4.84x10-1 4.63x10-7 NA
rs3759929 15 FURIN 0.39 7.29x10-1 rs780825 10 CUBN 0.31 9.54x10-1 5.18x10-7 NA
rs2740502 19 KLK1 0.40 6.61x10-1 rs7910038 10 PRKCQ 0.47 8.08x10-1 5.64x10-7 6.24x10-1
rs3748107 7 SBDS 0.28 2.95x10-1 rs7130671 11 NCAM1 0.35 3.48x10-1 6.2x10-7 7.73x10-2
rs7629902 3 RARB 0.15 2.03x10-1 rs6472228 8 PDE7A 0.15 5.59x10-1 7.26x10-7 8.98x10-1
rs2245121 10 SFTPD 0.43 2.28x10-1 rs4418583 1 LDLRAP1 0.50 7.18x10-1 7.51x10-7 NA
rs613089 1 BCL9 0.31 6.00x10-1 rs11466521 3 TGFBR2 0.23 9.28x10-1 8.79x10-7 NA
rs9862 22 TIMP3 0.49 3.40x10-1 rs753424 1 HMGCS2 0.46 5.34x10-1 1.09x10-6 3.01x10-1
rs11807878 1 BCL9 0.12 1.14x10-1 rs12060491 1 PDE4B 0.17 1.82x10-1 1.15x10-6 1.61x10-2

SNP: single nucleotide polymorphism, Chr: chromosome; MAF: minor allele frequency; BHF-FHS: British Heart Foundation Family Heart Study; MIGen: Myocardial Infarction Genetics Consortium; SNPA Pvalue: level of nominal statistical significance for single marker association with coronary artery disease for SNP A; SNPB Pvalue: level of nominal statistical significance for single marker association with coronary artery disease for SNP B; Int. Pvalue BHF-FHS: interaction P value in BHF-FHS; Int. Pvalue MIGen: interaction P value in MIGen; N/A: replication not available. FRMD4B: FERM domain containing 4B; PLA2G4A: phospholipase A2, group IVA; FURIN: furin (paired basic amino acid cleaving enzyme); CUBN: cubilin (intrinsic factor-cobalamin receptor); KLK1: kallikrein 1; PRKCQ protein kinase C, theta; SBDS: Shwachman-Bodian-Diamond syndrome; NCAM1: neural cell adhesion molecule 1; RARB: retinoic acid receptor, beta; PDE7A: phosphodiesterase 7A; SFTPD: surfactant protein D; LDLRAP1: low density lipoprotein receptor adaptor protein 1; BCL9: B-cell CLL/lymphoma 9; TGFBR2: transforming growth factor, beta receptor II (70/80kDa); TIMP3: TIMP metallopeptidase inhibitor 3; HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); PDE4B: phosphodiesterase 4B, cAMP-specific.