Table 3. Suggestive SNP-SNP interactions—secondary analysis.
| SNPA | ChrA | Gene | MAF | SNPA Pvalue | SNPB | ChrB | Gene | MAF | SNPB Pvalue | Int. Pvalue BHF-FHS | Int. PvalueMIGen |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs9840469 | 3 | FRMD4B | 0.38 | 7.00x10-4 | rs10911935 | 1 | PLA2G4A | 0.21 | 4.84x10-1 | 4.63x10-7 | NA |
| rs3759929 | 15 | FURIN | 0.39 | 7.29x10-1 | rs780825 | 10 | CUBN | 0.31 | 9.54x10-1 | 5.18x10-7 | NA |
| rs2740502 | 19 | KLK1 | 0.40 | 6.61x10-1 | rs7910038 | 10 | PRKCQ | 0.47 | 8.08x10-1 | 5.64x10-7 | 6.24x10-1 |
| rs3748107 | 7 | SBDS | 0.28 | 2.95x10-1 | rs7130671 | 11 | NCAM1 | 0.35 | 3.48x10-1 | 6.2x10-7 | 7.73x10-2 |
| rs7629902 | 3 | RARB | 0.15 | 2.03x10-1 | rs6472228 | 8 | PDE7A | 0.15 | 5.59x10-1 | 7.26x10-7 | 8.98x10-1 |
| rs2245121 | 10 | SFTPD | 0.43 | 2.28x10-1 | rs4418583 | 1 | LDLRAP1 | 0.50 | 7.18x10-1 | 7.51x10-7 | NA |
| rs613089 | 1 | BCL9 | 0.31 | 6.00x10-1 | rs11466521 | 3 | TGFBR2 | 0.23 | 9.28x10-1 | 8.79x10-7 | NA |
| rs9862 | 22 | TIMP3 | 0.49 | 3.40x10-1 | rs753424 | 1 | HMGCS2 | 0.46 | 5.34x10-1 | 1.09x10-6 | 3.01x10-1 |
| rs11807878 | 1 | BCL9 | 0.12 | 1.14x10-1 | rs12060491 | 1 | PDE4B | 0.17 | 1.82x10-1 | 1.15x10-6 | 1.61x10-2 |
SNP: single nucleotide polymorphism, Chr: chromosome; MAF: minor allele frequency; BHF-FHS: British Heart Foundation Family Heart Study; MIGen: Myocardial Infarction Genetics Consortium; SNPA Pvalue: level of nominal statistical significance for single marker association with coronary artery disease for SNP A; SNPB Pvalue: level of nominal statistical significance for single marker association with coronary artery disease for SNP B; Int. Pvalue BHF-FHS: interaction P value in BHF-FHS; Int. Pvalue MIGen: interaction P value in MIGen; N/A: replication not available. FRMD4B: FERM domain containing 4B; PLA2G4A: phospholipase A2, group IVA; FURIN: furin (paired basic amino acid cleaving enzyme); CUBN: cubilin (intrinsic factor-cobalamin receptor); KLK1: kallikrein 1; PRKCQ protein kinase C, theta; SBDS: Shwachman-Bodian-Diamond syndrome; NCAM1: neural cell adhesion molecule 1; RARB: retinoic acid receptor, beta; PDE7A: phosphodiesterase 7A; SFTPD: surfactant protein D; LDLRAP1: low density lipoprotein receptor adaptor protein 1; BCL9: B-cell CLL/lymphoma 9; TGFBR2: transforming growth factor, beta receptor II (70/80kDa); TIMP3: TIMP metallopeptidase inhibitor 3; HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); PDE4B: phosphodiesterase 4B, cAMP-specific.