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. 2015 Feb 5;96(2):221–234. doi: 10.1016/j.ajhg.2014.12.024

Figure 3.

Figure 3

UBE2L3 and LUBAC Augment Late-Phase NF-κB Activation in Response to TNF

(A) Increased production of LUBAC in combination with UBE2L3 augments NF-κB activation after 10 hr of TNF stimulation. This augmentation of the TNF response is abrogated by variant p.Cys86Ser UBE2L3 or variant p.Cys885Ser HOIP.

(B) Time course showing NF-κB activation after TNF stimulation in response to increased synthesis of LUBAC and UBE2L3. Maximal dysregulation of NF-κB occurs in the late-phase response to TNF. Error bars represent standard error of the mean.