Figure 2.

Theoretical and Observed Prediction Accuracy of STGBLUP and MTGBLUP Depending on Sample Size

Theoretical line of prediction accuracy increased with larger sample size (solid line), the observed accuracy achieved by STGBLUP with the actual sample size (red dot), and the observed accuracy achieved by MTGBLUP and inferred sample size (blue dot). The increase from MTGBLUP equates to ∼4,660 samples for schizophrenia, ∼5,550 samples for bipolar disorder, and ∼10,940 for major depressive disorder. The vertical error bars denote 95% CI. We note that the estimates for the different methods are highly correlated, and therefore the vertical error bars cannot be used to infer significance of difference between the methods (see Appendix C).