Skip to main content
. 2014 Nov 25;20(1):140–147. doi: 10.1038/mp.2014.145

Figure 2.

Figure 2

Effects of gene dosage on local brain volume and tissue properties. Results of voxel-based whole-brain general linear analyses showing: (a) negative gene dosage effect (DEL>CTRL>DUP) on GM volume in ventral striatum, thalamus, superior temporal region, fusiform, precuneus, insula and calcarine sulci bilaterally as well as in right occipital region. (b) Positive gene dosage effect (DEL<CTRL<DUP) on GM volume in the middle temporal gyrus and in cerebellar lobule VIII, VIIb and crus II. (c) Negative gene dosage effect on WM volume within fronto-striatal projections, anterior thalamic and superior longitudinal fasciculus. (d) Absence of significant positive gene dosage effect on WM volume. (e and f) FA and MD changes overlapping with GM changes in superior temporal gyrus and caudate bilaterally. For representation purposes, results significant at a voxel level at threshold of P<0.05 family-wise error corrected for multiple comparisons are displayed at significance threshold of P<0.001 uncorrected at voxel level in standard Montreal Neurological Institute space. Color bars represent T scores. DEL, deletion carriers; CTRL, intrafamilial controls; DUP, duplication carriers; GM, gray matter; WM, white matter; FA, fractional anisotropy; MD, mean diffusivity.