Table 1. SNPs associated with risk of relapse discovered in both Danish and German cohorts.

SNP			NOPHO ALL92 and 2000				BFM ALL2000				Combined cohorts
Rs ID	Gene	Cons	P-value	OR	MAF relapse	MAF CR	P-value	OR	MAF relapse	MAF CR	MAF relapse	MAF CR	P-value	OR
Rs3216144	MMP7	Regulatory	4.0E−04	0.14	0.05	0.26	2.0E−03	0.32	0.09	0.24	0.07	0.24	6.0E−06	0.26
Rs10502001	MMP7	NSC	4.0E−04	0.14	0.05	0.25	2.0E−03	0.32	0.09	0.24	0.08	0.24	6.0E−06	0.26
Rs10795242	AKR1C3	Intronic	8.6E−03	2.13	0.31	0.17	3.7E−02	1.85	0.24	0.15	0.27	0.16	5.0E−04	2.01
Rs28730837	MPO	NSC	4.7E−02	4.26	0.06	0.02	1.5E−02	3.19	0.06	0.02	0.06	0.02	1.0E−03	3.60
Rs6139873	CHGB	NSC	4.0E−03	19.56	0.11	0.01	3.9E−02	3.50	0.04	0.01	0.06	0.01	1.1E−03	5.75
Rs1293945	ESR1	Regulatory	2.0E−02	1.86	0.59	0.43	2.6E−02	1.95	0.59	0.42	0.59	0.43	1.3E−03	1.91
Rs3763156	LMNB1	Intronic	2.0E−02	3.06	0.19	0.07	4.0E−02	2.15	0.15	0.07	0.16	0.07	1.6E−03	2.43
Rs55684978	HTR3D	SC	1.6E−02	8.08	0.07	0.01	3.2E−02	3.85	0.04	0.01	0.05	0.01	1.8E−03	4.88
Rs1058047	TMED7	Splice site	1.3E−02	8.64	0.08	0.01	3.9E−02	3.20	0.05	0.02	0.06	0.02	3.1E−03	3.98
Rs35721373	DYSF	SC	1.5E−02	4.89	0.13	0.03	3.1E−02	2.52	0.09	0.04	0.10	0.04	3.3E−03	2.96
Rs6601899	AKR1C3	Intronic	3.9E−02	1.77	0.31	0.20	3.6E−02	1.80	0.24	0.15	0.27	0.17	3.3E−03	1.84

Abbreviations: cons, consequence of the SNP on its transcript from Ensembl Variant Effect Predictor; MAF CR, minor allele frequency in complete remission patients; MAF relapse, minor allele frequency in relapse patients; NSC, nonsynonymous coding; OR, odds ratio; P-value, adaptive permutation P-values; SC, synonymous coding.