Table 2. Clinical characteristics of the patients in the three CART groups.
| Characteristics | Group [A] patients | Group [B] patients | Group [C] patients |
|---|---|---|---|
| Total patients (%) | 305 (71.5) | 100 (23.5) | 21 (5) |
| Gender | |||
| Male | 174 (57) | 63 (63) | 12 (57) |
| Female | 131 (43) | 37 (37) | 9 (43) |
| Age (years), mean (50% range) | 5.32 (2.89–6.71) | 7.38 (3.54–10.97) | 7.09 (3.75–10.88) |
| WBC × 109/l, mean (50% range) | 22.88 (4.6–26.5) | 100.36 (7.5–108) | 90.61 (4.51–121) |
| Immunophenotype | |||
| BCP-ALL | 279 (91.5) | 77 (77) | 17 (81) |
| T-ALL | 25 (8.2) | 23 (23) | 4 (19) |
| Other | 1 (0.3) | 0 (0) | 0 (0) |
| MRD | |||
| Low | 237 (77.7) | 67 (67) | 12 (57) |
| High | 68 (22.3) | 33 (33) | 9 (43) |
| Cytogenetics | |||
| t(9;22) | 4 (1.3) | 1 (1) | 1 (4.8) |
| t(1;19) | 3 (1) | 1 (1) | 0 (0) |
| t(12;21) | 79 (25.9) | 13 (13) | 2 (9.5) |
| t(4;11) | 2 (0.65) | 1 (1) | 0 (0) |
| Hypodiploid | 2 (0.65) | 3 (3) | 0 (0) |
| Hyperdiploid | 81 (26.5) | 16 (16) | 1 (4.8) |
| Other | 17 (5.6) | 5 (5) | 2 (9.5) |
| Normal/no data | 120 (39.3) | 61 (61) | 15 (71.4) |
| Relapse distribution | |||
| Total | 11 | 23 | 14 |
| Bone marrow | 8 (72.7) | 19 (82.6) | 12 (85.7) |
| CNS | 1 (9.1) | 3 (13.1) | 4 (28.6) |
| Other | 2 (18.2) | 2 (8.7) | 0 (0) |
Abbreviations: ALL, acute lymphoblastic leukemia; BCP-ALL, B-cell precursor ALL; CART, classification and regression tree; CNS, central nervous system relapses (isolated and combined CNS relapses); MRD, minimal residual disease; T-ALL, T-lineage acute lymphoblastic leukemia; WBC, white blood cell count.