Figure 1.

Beclinl transcript expression in postmortem hippocampus and lymphocytes of schizophrenia patients compared to healthy controls. (a) Hippocampus (**P<0.01). (b) Lymphocytes (no significant change). Results (% of control) are depicted as means +/− s.e.m (c, d). Age-dependence of the expression in postmortem hippocampus. (c) Beclinl did not correlate with age, although a trend of decrease with age was seen in the control subjects (Pearson's correlation, r=−0.429, P=0.164). (d) Bcl2 was significantly increased with age in the control subjects (Pearson's correlation, r=0.639, P<0.05). In contrast, Bcl2 expression did not correlate with age in hippocampal samples from the schizophrenia post-mortem brains. Control (CON)-closed circles, heavy line; schizophrenia (SCZ), squares with hairy +, light line. Expression levels=2^−Δ Ct times 100. (e, f) Lymphocyte Bcl2 expression. (e) Bcl2 mRNA levels were significantly increased in schizophrenia patients compared to healthy age-matched controls (*P<0.05). Results were calculated as means +/−s.e.m, and relative expression as % of control. (f) A trend toward increased Bcl2 mRNA levels with age was observed only in the healthy cohort, similar to the results in the hippocampal samples (d) Control (CON)-closed circles, heavy line; schizophrenia (SCZ), squares with hairy +, light line. Expression levels=2^−Δ Ct times.