Table 1.
Scheme for the systematic assessment of histological features in liver cell nodules in cirrhotic livers
| Feature | Modality of assessment | |||||
| Nodule maximum diameter | Measurement in millimeter | |||||
| Solitary arterioles | Average of individual arteries ×100 (medium power field, MPF) fields | |||||
| Mitotic activity | Number of mitoses per 10 ×400 (10 high power fields, 10 HPF) fields | |||||
| Trabecular thickness | Number of liver cells forming trabecular (LCT) width | |||||
| Vascular invasion | Present/absent | |||||
| Capsular invasion | Present/absent | |||||
| Necrosis2 | Present/absent | |||||
| Nodule heterogeneity1 | Present/absent | |||||
| Reticulin loss3 | None | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Capillarization (CD34)3 | None | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Cellular atypia3 | None | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
1
Phenotypically recognizable “clonal” changes e.g. clear cell change, fatty change, microacinar structures;
2
excluding post-treatment necrosis;
3
see text pages 5-6.