Table 1.
n = 95 patients | |
Female:male | 58:37 patients |
Age (yr) | 43 years (range 20–74 yr) |
UC:CD | 42:53 patients |
Duration of IBD at start 6-TG | 10.4 yr (SD 9.4 yr) |
AZA intolerance | 78 patients (82%) |
6-MP intolerance | 4 patients (4%) |
AZA and 6-MP intolerance | 13 patients (14%) |
AZA or 6-MP rechallenge | 36 patients (38%) |
Adverse events on AZA or 6MP: | 30% gastrointestinal complaints |
20% general malaise | |
14% allergic reactions | |
10% pancreaticotoxicity | |
6% hepatotoxicity | |
5% myelotoxicity | |
14% rest (e.g., myalgia or alopecia) | |
6-TG dosage at the start | 24.6 mg (range 20-40 mg) |