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. 2015 Feb 1;13:43. doi: 10.1186/s12967-015-0399-y

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© Doudican et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MM patient 1 profile schematic. The key signaling pathways and crosstalk relevant for MM patient 1 are presented. The profile includes chromosome 13 monosomy, loss of chromosome 17p13.1, heterozygous deletions of tumor suppressors RB1 and FOXO1 and a homozygous deletion of P53. Genes presented in green exhibit reduced expression. This profile displayed high AKT activation due to reduced PTEN and IGFBP3 expression, which are downstream of P53. Also, the simulation avatar predicted high BCL2 levels. The combination of BEZ235 (PI3K/mTOR inhibitor) and ABT199 (BCL2 mimetic) was predicted to result in a synergistic reduction in proliferation and viability endpoints.