Table 2.
Comparison of intraocular, systemic and perfusion pressures (mmHg) in the 2 groups
| Bimatoprost | LTFC | p-value | |
|---|---|---|---|
| Baseline IOP (sd) | 16.3 (3.3) | 15.5 (2.9) | 0.2 |
| Baseline nocturnal IOP (sd) | 16.9 (3.6) | 16.0 (3.3) | 0.3 |
| Baseline SBP (sd) | 136.5 (18.3) | 134.2 (20.1) | 0.1 |
| Baseline DBP (sd) | 79.1 (10.2) | 78.2 (10.1) | 0.4 |
| Baseline nocturnal SBP (sd) | 121.0 (13.8) | 122.1 (15.8) | 0.3 |
| Baseline nocturnal DBP (sd) | 72.7 (7.9) | 73.2 (9.5) | 0.4 |
| Baseline SPP (sd) | 120.2 (15.7) | 118.7 (16.8) | 0.3 |
| Baseline DPP (sd) | 62.8 (6.9) | 62.7 (8.2) | 0.6 |
| Baseline nocturnal SPP (sd) | 104.1 (13.1) | 106.1 (16.4) | 0.2 |
| Baseline nocturnal DPP (sd) | 55.8 (8.0) | 57.2 (12.1) | 0.1 |
| 12 week IOP (sd) | 16.1 (2.5) | 16.3 (3.7) | 0.7 |
| 12 week nocturnal IOP (sd) | 16.1 (2.6) | 16.1 (3.9) | 0.8 |
| Holter SBP (sd) | 135.1 (16.7) | 128.1 (15.3) | 0.04 |
| Holter DBP (sd) | 79.5 (8.3) | 78.7 (11.8) | 0.4 |
| Holter nocturnal SBP (sd) | 124.8 (14.4) | 120.0 (14.5) | 0.08 |
| Holter nocturnal DBP (sd) | 71.7 (7.9) | 70.6 (11.3) | 0.2 |
| Holter SPP (sd) | 119.0 (10.8) | 111.8 (15.3) | 0.03 |
| Holter DPP (sd) | 63.4 (8.0) | 62.4 (11.1) | 0.1 |
| Holter nocturnal SPP (sd) | 108.7 (14.4) | 103.9 (17.3) | 0.07 |
| Holter nocturnal DPP (sd) | 55.6 (7.4) | 54.5 (12.3) | 0.2 |
LTFC: latanoprost/timolol fixed combination; IOP: intraocular pressure; sd: standard deviation; SBP: systolic blood pressure; DBP: diastolic blood pressure; SPP: systolic perfusion pressure; DPP: diastolic perfusion pressure.