Table 3.

Association of baseline body composition measures and adipokines with rapid decline^* and incident CKD^**by cystatin C in HIV-infected FRAM participants

	Rapid decline (N = 125)	Incident CKD (N = 51)
(results are per doubling)	Adjusted odds ratio (95% CI) *** single measures)	Adjusted odds ratio (95% CI) *** (single measures)
MRI-measured body composition:
VAT	0.91 (0.76, 1.08) p=0.29	0.94 (0.72, 1.22) p=0.65
Skeletal Muscle	0.62 (0.23, 1.65) p=0.33	0.65 (0.16, 2.6) p=0.54
Total Fat	0.88 (0.66, 1.16) p=0.36	0.95 (0.63, 1.44) p=0.82
Arm SAT	0.83 (0.57, 1.20) p=0.32	0.81 (0.47, 1.41) p=0.45
Leg SAT	0.87 (0.65, 1.17) p=0.37	1.03 (0.67, 1.57) p=0.89
Upper Trunk SAT	0.85 (0.65, 1.10) p=0.21	0.82 (0.55, 1.20) p=0.30
Lower Trunk SAT	0.96 (0.76, 1.20) p=0.70	1.12 (0.80, 1.56) p=0.51
Adipokines:
Adiponectin	1.11 (0.90, 1.38) p=0.33	1.11 (0.80, 1.53) p=0.54
Leptin	0.93 (0.75, 1.14) p=0.49	1.03 (0.75, 1.41) p=0.85

^*Rapid decline defined as annual eGFR loss ≥3 mL/min/1.73m²

^**CKD defined as eGFR< 60ml/min/1.73m² and decline in eGFR of > 1ml/min/year. Persons with CKD at baseline are excluded from analysis. Multiple imputation is used to impute missing covariates.

^***covariates in fully adjusted model include age, race, gender, DM, albumin, viral load, change in viral load.