Figure 1.

In vivo comparison of repair by SiO2NP nanobridging, by suturing, and by cyanoacrylate glue of full-thickness dorsal skin injury in a Wistar rat model. A drop of SiO2NP solution was put onto a wound edge with a brush and the two wound edges were gently pressed into contact for about a minute. The other wounds were closed with a non-resorbable suture (Ethicon 4/0) and 2-octyl cyanoacrylate (Dermabond). At day 3 post-surgery, no wound leakages, infection, or inflammatory reactions were observed after nanobridging with SiO2NP. The rat skin closure achieved with nanoparticles and the suture were comparable. For the cyanoacrylate glue, the wound edges were not bonded correctly. Histological sections were stained with Hematoxylin-Phloxin-Saffron stain.