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. 2014 Sep 26;66(10):2739–2750. doi: 10.1002/art.38772

Figure 1.

Figure 1

Edema, clinical severity, and inflammatory vascular leakage in PACAP+/+ (wild-type) and PACAP−/− mice in which arthritis was not induced (controls administered normal serum) or in which arthritis was induced by administration of K/BxN mouse serum. A and B, Plethysmometric determination of hind paw volumes (A) and clinical scores of disease severity (B) (n = 8−12 per group). C, Representative images of indocyanine green (ICG) fluorescence in the ankle joints, as an indicator of vascular permeability and leakage. Images were obtained 5 minutes and 60 minutes after intravenous injection of ICG (0.5 mg/kg). D, ICG fluorescence intensity ([photons/second/cm2/steradian]/[μW/cm2] [p/s/μW/cm2]) in the ankle joints 2 days and 5 days after induction of arthritis (n = 5−6 per group). Values in A, B, and D are the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001 versus the respective control group. # = P < 0.05; ## = P < 0.01; ### = P < 0.001 versus the K/BxN serum−treated wild-type group. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.38772/abstract.