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. 2014 Sep 26;66(10):2739–2750. doi: 10.1002/art.38772

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© 2014 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Bioluminescence imaging of neutrophil-derived myeloperoxidase activity and macrophage-derived superoxide activity. A and B, Representative images of luminol activity obtained 10 minutes after intraperitoneal injection of Na-luminol (150 mg/kg) (A) and quantification of luminescence in diseased ankle joints (B). C and D, Representative images of lucigenin-based superoxide detection (C) and quantification of luminescence in diseased ankle joints 10 minutes after intraperitoneal injection of lucigenin (25 mg/kg) (D). Values in B and D are the mean ± SEM photons/second (p/s) (n = 4−6 per group). ∗ = P < 0.05 versus control PACAP^+/+ mice; ## = P < 0.01. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.38772/abstract.