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. 2015 Feb 5;16(1):45. doi: 10.1186/s12864-015-1270-5

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© Zuo et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The cooperated regulation of transcription factors on lncRNAs upon LPS stimulation in BMDMs. (A) Ecdf plots demonstrate the expression difference between transcription factor targets (red: elncRNA; blue: plncRNA) and all lncRNAs (black) (P values are from two-sided KS-test). (B) Venn diagrams of the numbers of overlapped lncRNAs bound by p65, IRF3, JunB and cJun upon LPS stimulation in BMDMs. (C) Heatmap showing that whether LPS-upregulated (red) and LPS-downregulated (green) lncRNAs were bound by transcription factors p65, IRF3, JunB, cJun and Bcl6. The red and green colors mean the lncRNAs were bound by the corresponding transcription factor, while the gray color means not bound.