Table 2. Prevalence and definitions of hypocalcemia and permanent hypoparathyroidism in national registries and large multicenter studies.
| Study | Year | No. of procedures | Postoperative hypocalcemia prevalence | Definition | Value | Timing of blood sampling | Permanent hypoparathyroidism prevalence | Definition | Time at diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| Hundahl et al. (7) (The ACS Commission on Cancer) | 2000 | 1,926 TT | Not available | Unspecified | Unspecified | Not available | 12.4% | Unspecified | Not available |
| Thomusch et al. (8) | 2003 | 5,846 BT | 24% | In ward calcium/vit D treatment | Unspecified | Not available | 9% | Undetectable PTH vitamin D or calcium supplementation | 6 months after surgery |
| Swedish register (9) | 2008 | 1,648 BT | 9.9% | Ca and/or vit D supplementation at discharge | Unspecified | Day 1 | 4.4% | Vit D and/or calcium supplementation | 6 months after surgery |
| Swedish register (10) (Graves’ disease) | 2012 | 956 TT | 13.6% | Ca and/or vit D supplementation at discharge | 4.3% | Vit D supplementation | 6 months after surgery | ||
| BAETS Fourth National Audit Report (11) | 2012 | 3,788 TT | 27.4% | Serum calcium | <2.1 mmol/L | Day 1 | 12.1% | Calcium/vit D supplementation | 6 months after surgery |
| Duclos et al. (12) | 2012 | 2,669 TT | Not available | Serum calcium | < 2 mmol/L | 48 h | 2.6% | Calcium/vit D supplementation | 6 months after surgery |
TT, total thyroidectomy; BT, bilateral thyroidectomy.