Figure 1.

Stroke or systemic embolic events subgroups (A) and major bleeding subgroups (B). Data are n/N, unless otherwise indicated. No data available from RE-LY for the following major bleeding subgroups: sex, creatinine clearance, diabetes, and CHADS₂ score. For ROCKET AF no major bleeding data available in the TTR and diabetes subgroup and major and non-major clinically relevant bleeding was used for subgroups of age, sex, CHADS₂ score, and creatinine clearance. NOAC, new oral anticoagulant; RR, risk ratio; TIA, transient ischemic attack; VKA, vitamin K antagonist; TTR, time in therapeutic range. [Reproduced with permission from (16)].