Skip to main content
. 2014 Oct 8;124(11):5027–5036. doi: 10.1172/JCI77495

Figure 8. Pcp4-null mice are prone to ventricular arrhythmias and aberrant ventricular conduction.

Figure 8

(A–E) Representative ECG tracings from anesthetized mice after administration of caffeine and epinephrine (CE). (A) Pcp4+/+ control mouse ECG demonstrates sinus tachycardia without ventricular ectopy. (B–E) Pcp4–/– mutant mouse ECGs demonstrate (B) isolated PVC; (C) monomorphic ventricular tachycardia (MMVT); (D) bidirectional ventricular tachycardia (BVT); and (E) aberrant ventricular conduction (AVC). (F) Comparison of PVC frequency between Pcp4+/+ and Pcp4–/– mice after caffeine and epinephrine. (G) Proportion of Pcp4-null mice that developed ventricular arrhythmias or AVC after caffeine and epinephrine (n > 11 ). Data represent mean ± SEM. *P < 0.05.