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. 2014 Jun 23;79(2):181–191. doi: 10.1111/tpj.12563

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© 2014 The Authors The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Model of stepwise association of silencing proteins with long non-coding RNA (lncRNA) produced by Pol V to mediate CHH methylation. At IDN2/IDNL1/IDNL2-dependent loci, AGO4 interacts with lncRNA produced by Pol V in a manner at least partially dependent on small interfering RNA (siRNA). In turn, IDN2 binds to lncRNA possibly recognizing a 5′-overhang of a double-stranded RNA consisting of siRNA and lncRNA. Finally, DRM2 directly or indirectly associates with the Pol V transcript in a way dependent on IDN2 and AGO4, and the DNA at the locus is methylated.