Table 1.
Pharmacokinetic parameters for single-dose s.c. administration of Genotropin and hGH-CDR3H-coil-Herceptin in Sprague–Dawley rats
| Parameter | Genotropin | hGH-CDR3H-coil-Herceptin |
| Cmax, ng/mL | 651 (±131) | 776 (±216) |
| Half-life, h | 0.8 (±0.2) | 37.0 (±-9.7) |
| AUC0→inf, h⋅µg−1⋅mL−1 | 2.70 (±0.54) | 49.9 (±13.9) |
| MRT, h | 2.9 (±0.3) | 58.5 (±7.7) |
| Cl/f, mL⋅h−1⋅kg−1 | 741 (±101) | 40 (±17) |
Single s.c. injection at a dosage of 2 mg/kg. Concentration vs. time curves were evaluated by noncompartmental analysis using WinNonlin. Values shown are averages of three rats in the group. AUC0→inf, area under the concentration–time curve extrapolated to infinity; Cl/f, plasma clearance; Cmax, maximum concentration; MRT, mean residence time.