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. 2015 Jan 20;112(5):E472–E477. doi: 10.1073/pnas.1415573112

Fig. 4.

Fig. 4.

Costs of misapplication of strategies. (A) Total fitness costs (combined vaccination cost and disease burden) of applying a boosting schedule evolved for each scenario in each other scenario. The representative boosting schedules are constructed by taking the mean coverage at each age in the most fit strategy family (as shown in Fig. 2). These representative schedules (strategy used) are applied to each scenario (actual scenario), and the mean fitness cost among 120 replicant runs is plotted. The disease burden (B) and cost of vaccination effort (C) of these same strategies are plotted (so that A shows the sum of B and C).