Fig. 7.

Patterning at the tissue level. (A and B) Representation of a 1D layer of 20 interacting cells. (A) The increase of the production of Delta $\left(D_0\right)$ leads to the formation of alternate patterns in which neighbor cells alternate between Sender and Receiver. (B) The increase of the production of Jagged leads all of the cells to the hybrid (S/R) state, therefore losing the alternate (S) and (R) pattern. (C and D) Average of the fraction of cells in (S), (S/R), or (R) state as a function of ligand production. The averages were taken over 100 simulations of a 1D layer of 100 interacting cells with periodic boundary condition. (C) Fraction of cells in (S), (S/R), or (R) state as a function of the production of Delta. (D) Fraction of cells in (S), (S/R), or (R) state as a function of the production of Jagged. The states of the cells are defined according to the amount of signaling (I): Sender $\left(I<100\right)$, Sender/Receiver $\left(100<I<300\right)$, and Receiver $\left(I>300\right)$. For this figure, we used $k_T=2.5e^{-5}$.