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. 2015 Jan 21;112(5):E450–E457. doi: 10.1073/pnas.1417988112

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Fig. 1. — B-cell development in V_HQ52^NT; Vκgr32^NT monoclonal mice. (A) IgH Southern blotting analysis of wild-type and V_HQ52^NT HT mice. Bands corresponding to IgH germ line (GL) and V_HQ52^NT alleles are indicated. (B) Structure of rearranged IgH and Igκ loci in IgA transnuclear mice. (C) Numbers of CD19⁺ B cells in SP and inguinal LNs of control (IgH^WT;IgL^WT) and IgA monoclonal mice (V_HQ52^NT; Vκgr32^NT; Rag1^−/−), determined by flow cytometric analysis. (D) Representative flow cytometric analysis of splenic CD19⁺-gated B cells in control (n = 2) and IgA monoclonal mice (n = 2). (E) Representative flow cytometric analysis of splenic CD19⁺ B cells in controls and IgA monoclonal mice (n = 2). Peritoneal cavity B cells were analyzed after gating, respectively, on IgM⁺ (IgH^WT;IgL^WT) or IgA⁺ (V_HQ52^NT; Vκgr32^NT; Rag1^−/−) cells (n = 2). Numbers indicate percentage of boxed B-cell subsets.