Table 1.

Demographic, iron, erythropoietic, and inflammatory indices for patients with HbE β-thalassemia overall and stratified by severe and moderate phenotype

Parameter	All patients (n = 69; 42 female)	Severe (n = 28; 17 female)	Moderate (n = 41; 25 female)	P for difference between moderate/severe	Local controls (n = 25)
Age, years*	26.6 (3-61)	17.5 (3-28)	32.8 (9-61)	<.0001†	16.6 (16.0, 17.2)
Hb, g/dL*	6.2 (4.4-8.3)	5.8 (4.4-7.6)	6.4 (4.9-8.3)	.1397	15.0 (14.5, 15.5)‡
HbF, %*	26.0 (6.2-51.2)	24.1 (6.2-42.4)	27.3 (6.4-51.2)	.3226	0.27 (0.19, 0.39)‡
Total transfusions*	47.6 (0, 143)	59.3 (3, 143)	39.7 (0, 123)	.0377†
Ferritin, mg/L**	947 (143, 9790)	1356 (328, 9790)	732 (143, 3260)	.0021†	48.2 (38, 61.2)‡
Liver iron, mg/gdwt**	7.21 (0.7, 54.2)	11.3 (1, 54.2)	5.30 (0.7, 29.0)	.0006†
NTBI, µM/L*	4.68 (−2.67, 23.75)	5.16 (−1.67, 10.27)	4.36 (−2.67, 23.75)	.4456
Hepcidin, ng/mL**	2.06 (0.1, 51.8)	2.24 (0.1, 51.8)	1.95 (0.1, 36.3)	.7441	28.23 (18.83, 42.3)‡
sTfR, nM/L**	7.83 (1, 35.3)	6.51 (1, 35.3)	8.87 (1.4, 35.3)	.1472
EPO, mg/L**	158 (28.7, 2196.7)	159 (28.7, 2196.7)	158 (34.5, 1296.5)	.9915
CRP, mg/L**	1.61 (0.20, 34.23)	1.66 (0.23, 34.23)	1.58 (0.20, 13.01)	.8433
GDF-15, pg/mL,**	8407 (1920, 60 229)	7011 (2125, 19 031)	9517 (1920, 60 229)	.0549
Labile plasma iron, µM/L*	4.01 (−1.07, 13.61)	3.60 (0.1, 7.7)	4.29 (−1.07, 13.61)	.9320
Transferrin SAT, %*	90.9 (31.9, 100.0)	97.3 (48.3, 100.0)	86.6 (31.9, 100.0)	.0319†
ALT, mg/L**	37.2 (5, 213)	48.2 (5, 213)	31.1 (5, 79)	.0170†

Values are *mean (range) or **geometric mean (range).

^†Significant difference between moderate and severe patients (P < .05).

^‡Significant difference between controls and overall patient group, severe patients, and moderate patients.