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. 2014 Nov 5;5(1):24–38. doi: 10.1002/brb3.295

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© 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Depolarized cell membrane causes mature neurons assemble into aggregates. (A) Cluster analysis; y axis of the plot is power spectral density and, x axis is spatial frequency, which has units of pixels⁻¹. Red line corresponds to Panel B image and blue to Panel C image. Single-channel images taken from (B) Ivm-treated cells (3 weeks cocultures, 1 μmol/L, 24 h) and (C) from Control (not treated with ivm) are shown here as representative. A large aggregate is equal to one and random organization (no aggregation) is 0. (D) Ivm caused significant neuronal aggregation. (E) A very little glial aggregation was observed (E). §P ≤ 0.01. N = 18 images, 54,000 cells in total. (F) Western blot data showing increased GLR production in cells with depolarized V_mem (Ivm). Band intensities were normalized to one taken as the highest intensity band.