Table 4. Recommended dosage and administration for the nonbenzodiazepine sedative hypnotics^1–7.

	Recommended dose	Maximum dose	Dose adjustments in special populations
Suvorexant	10 mg once daily within 30 minutes of going to bed	20 mg once daily	With moderate CYP3A inhibitors, the recommended dose is 5 mg and the maximum dose is 10 mg. Not recommended in patients requiring treatment with a strong CYP3A inhibitor
Doxepin	3 to 6 mg within 30 minutes of going to bed	6 mg/day	Recommended starting dose is 3 mg in the elderly and those with hepatic impairment
Eszopiclone	1 mg immediately before bedtime	3 mg once daily	Not to exceed 2 mg in the elderly or debilitated, in patients with severe hepatic impairment, or with coadministration of potent CYP3A4 inhibitors
Ramelteon	8 mg within 30 minutes of going to bed	8 mg per day	None
Zaleplon	5 to 10 mg immediately before bedtime	20 mg once daily	In the elderly or debilitated, the recommended dose is 5 mg and maximum dose is 10 mg. In mild to moderate hepatic impairment, the recommended dose is 5 mg. With cimetidine, the initial dose is 5 mg.
Zolpidem extended release	6.25 mg for women and 6.25 or 12.5 mg for men immediately before bedtime	12.5 mg once daily	Recommended dose is 6.25 mg for the elderly and those with hepatic impairment.
Zolpidem tablets	5 mg for women and 5 to 10 mg for men immediately before bedtime	10 mg once daily	Recommended dose is 5 mg in the elderly and debilitated, and those with hepatic impairment.