Table 1.
HD ID | Death | Onset | Duration | CAG repeat size | PMI (h) | Striatal score | Control ID | Death | PMI (h) |
---|---|---|---|---|---|---|---|---|---|
(A) Brain samples analyzed for FACS-ChIP-sequencing | |||||||||
HD-1 | 55 | 44 | 11 | 45 | 37 | 2.66 | C-1 | 55 | 40 |
HD-2 | 56 | 40 | 16 | 45 | 19 | 2.66 | C-2 | 56 | 17 |
HD-3 | 71 | 52 | 19 | 43 | 21 | 2.43 | C-3 | 71 | 24 |
HD-4 | 69 | 50 | 19 | 42 | 19 | 2.48 | C-4 | 69 | 18 |
HD-5 | 43 | 28 | 15 | 49 | 21 | 2.70 | C-5 | 43 | 12 |
HD-6 | 68 | 45 | 23 | 42 | 4 | 2.67 | |||
(B) Brain samples analyzed for DNA methylation | |||||||||
HD-2 | 56 | 40 | 16 | 45 | 19 | 2.66 | C-7 | 66 | 19 |
HD-3 | 71 | 52 | 19 | 43 | 21 | 2.43 | C-8 | 69 | 15 |
HD-4 | 69 | 50 | 19 | 42 | 19 | 2.48 | C-9 | 54 | 24 |
HD-5 | 43 | 28 | 15 | 49 | 21 | 2.70 | C-10 | 61 | 10 |
HD-6 | 68 | 45 | 23 | 42 | 4 | 2.67 | C-12 | 44 | 28 |
HD-7 | 89 | 70 | 19 | 40 | 57 | 3.33 | C-13 | 53 | 24 |
HD-8 | 69 | 63 | 6 | 41 | 6 | 2.64 | C-14 | — | — |
HD-9 | 67 | 40 | 27 | 44 | 14 | 3.33 | C-15 | 57 | 20 |
HD-10 | 61 | 35 | 26 | 46 | 25 | 3.58 | C-16 | 43 | 15 |
HD-11 | 63 | 40 | 23 | 45 | 21 | 2.74 | C-17 | 52 | 23 |
HD-12 | 62 | 40 | 22 | 45 | 28 | 3.58 | C-18 | 58 | 20 |
HD-13 | 76 | 58 | 18 | 41 | 7 | — | C-19 | 70 | 21 |
HD-14 | 48 | 25 | 23 | 48 | 19 | 3.82 | C-20 | 46 | 30 |
HD-15 | 40 | 34 | 6 | 51 | — | 3.52 | C-21 | 66 | 17 |
HD-16 | 55 | 31 | 24 | 47 | 24 | — | C-23 | 36 | 21 |
HD-17 | 72 | 55 | 17 | 41 | 8 | 2.59 | C-24 | 60 | 24 |
HD-18 | 67 | 48 | 19 | 43 | 22 | 2.74 | C-25 | 54 | 24 |
HD-19 | 59 | 35 | 24 | 46 | 6 | 2.62 | C-27 | 61 | 17 |
HD-20 | 72 | 55 | 17 | 42 | 12 | 2.74 | C-28 | 62 | 18 |
HD-21 | 78 | 62 | 16 | 42 | 18 | — | C-29 | 55 | 26 |
HD-22 | 68 | 52 | 16 | 42 | 13 | 2.66 | C-30 | 52 | 18 |
HD-23 | 57 | 40 | 17 | 49 | 25 | 2.91 | C-31 | 69 | 26 |
HD-24 | 53 | 40 | 13 | 48 | 23 | 3.60 | C-32 | 61 | 25 |
HD-25 | 48 | 38 | 10 | 45 | 11 | 3.60 | C-33 | 64 | 19 |
HD-26 | 36 | 24 | 12 | 54 | 21 | 2.91 | C-34 | 88 | 11 |
C-35 | 71 | 40 | |||||||
C-36 | 68 | 25 | |||||||
(C) Brain samples analyzed for qPCR analysis of mRNA | |||||||||
HD-2 | 56 | 40 | 16 | 45 | 19 | 2.66 | C-10 | 61 | 10 |
HD-3 | 71 | 52 | 19 | 43 | 21 | 2.43 | C-11 | 68 | 19 |
HD-4 | 69 | 50 | 19 | 42 | 19 | 2.48 | C-12 | 44 | 28 |
HD-5 | 43 | 28 | 15 | 49 | 21 | 2.7 | C-13 | 53 | 24 |
HD-6 | 68 | 45 | 23 | 42 | 4 | 2.67 | C-15 | 57 | 20 |
HD-8 | 69 | 63 | 6 | 41 | 6 | 2.64 | C-18 | 58 | 20 |
HD-16 | 55 | 31 | 24 | 47 | 24 | — | C-19 | 70 | 21 |
HD-17 | 72 | 55 | 17 | 41 | 8 | 2.59 | C-22 | 73 | 19 |
HD-19 | 59 | 35 | 24 | 46 | 6 | 2.62 | C-24 | 60 | 24 |
HD-21 | 78 | 62 | 16 | 42 | 18 | — | C-26 | 76 | 26 |
HD-22 | 68 | 52 | 16 | 42 | 13 | 2.66 | C-28 | 62 | 18 |
HD-24 | 53 | 40 | 13 | 48 | 23 | 3.6 | C-31 | 69 | 26 |
HD-25 | 48 | 38 | 10 | 45 | 11 | 3.6 | C-34 | 88 | 11 |
HD-26 | 36 | 24 | 12 | 54 | 21 | 2.91 | C-37 | 93 | 13 |