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Crystal structure of apo CH65 Fab. (a) Overall Fab structure with the heavy chain and light chain colored green and yellow, respectively. The HCDR3 is shown as thick tubes. The variable and constant Ig domains for each antibody chain are labeled. (b) The 2F o − F c electron-density simulated-annealing OMIT map of the CH65 HCDR3 loop is shown as a gray mesh and is contoured at 1.0σ.
