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. 2015 Feb 9;9:21. doi: 10.3389/fncel.2015.00021

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Copyright © 2015 Ramos-Chávez, Rendón-López, Zepeda, Silva-Adaya, Del Razo and Gonsebatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Water intake and As species in urines and brain tissue (A) Water intake of pregnant females and their litters. Daily water intake in was estimated by daily weighing the water bottles. Significant differences were observed only during lactation. (B) As species in pregnant female urine were determined in control and exposed females (n = 6) on days 15–18 of gestation. 24 h urine collection was performed using a metabolic cage. (C) iAs and As species in whole brain on PND 1 and PND 15 in male (D) and female (E) pups, when sex and brain regions could be identified. Accumulation of As was observed only in the liver during lactation, n = 6. One pup was randomly chosen from each litter. The values are expressed as mean ± SE; *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group. iAs: inorganic arsenic, MMA: monomethylarsenic, DMA: dimethylarsenic, TAs (iAs + MMA + DMA): total arsenic.