. 2015 Jan 29;8:313–321. doi: 10.2147/OTT.S64660

Table 2.

Adverse effects of everolimus in the treatment of advanced renal cell carcinoma in Chinese patients, as referenced against the effects in Western patients

Study	All grades				Grades 3/4
Study	Events	Incidence (%)	Incidence in RECORD-1 (updated)²⁹ (%)	Incidence in RECORD-1²⁸ (%)	Events	Incidence (%)	Incidence in RECORD-1 (updated)²⁹ (%)	Incidence in RECORD-1²⁸ (%)
Guo et al²⁷	Anemia	64	92	91	Anemia	20	13	<10
	Hypertriglyceridemia	55	73	71	Hyperglycemia	13	<16	12
	Mouth ulceration	53	44^a	40^a	Increased GGT	11	–	–
	Hyperglycemia	52	57	50	Hyponatremia	8	–	–
	Hypercholesterolemia	50	77	76	Dyspnea	8	24	7
	Pyrexia	41	20	–	Hypertriglyceridemia	6	<1	<1
	Increased lactate dehydrogenase	38	–	–	Lymphopenia	6	18	0
	Fatigue	31	31	20	Noninfectious pneumonitis	6	4	3
	Increased GGT	31	–	–
	Rash	31	29	25
	Noninfectious pneumonitis^b	31	14^b	8^b
Huang et al³⁰	Anemia	70.8	92	91	Anemia	25.0	13	<10
	Hypercholesterolemia	66.7	77	76	Hyperglycemia	16.7	<16	12
	Hypertriglyceridemia	65.0	73	71	Mucositis	8.3	1	1
	Mucositis	54.2	19	14	Pneumonitis	8.3	4	3
	Hyperglycemia	50.0	57	50	Raised ALP	8.3	–	<1
	Rash	45.8	29	25
	Raised ALP	25.0	–	37
	Thrombocytopenia	20.8	–	20
	Raised AST/ALT	20.5	25/21^c	21/18^c
	Pneumonitis	16.4	14	8

Notes:

References analyzed stomatitis which includes aphthous stomatitis, mouth ulceration, and stomatitis

noninfectious pneumonitis in the study by Guo et al includes interstitial lung disease, pneumonitis, and pulmonary fibrosis. References analyzed pneumonitis which includes interstitial lung disease, lung infiltration, pneumonitis, pulmonary alveolar hemorrhage, alveolitis, and pulmonary toxicity.

Incidence of AST and ALT was listed according to the reference, respectively.

Abbreviations: GGT, gamma-glutamyl transferase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; RECORD-1, renal cell cancer treatment with oral RAD001 given daily.