Table 1.
Chemical structures and in vitro MIC and MBC [µg/mL] values of tested 5- and 4-chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides (bactericidal effect of individual compounds against particular strains marked in bold).
| |||||||||||
|
| |||||||||||
| Comp. | R1 | R2 | R3 | MIC [µg/mL] | MBC [µg/mL] | ||||||
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | ||||
|
| |||||||||||
| 1a | 5-Cl | 4-CH3 | (S)-CH3 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| 1b | 5-Cl | 4-CH3 | (S)-CH(CH3)2 | >256 | >256 | 32 | 32 | >256 | >256 | 128 | >256 |
| 1c | 5-Cl | 4-CH3 | (S)-benzyl | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| 1d | 5-Cl | 4-CH3 | (R)-CH2-indolyl | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| 1e | 5-Cl | 4-OCH3 | (S)-CH(CH3)2 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| 1f | 5-Cl | 4-CF3 | (S)-CH(CH3)2 | 4 | 2 | 2 | 2 | 4 | 4 | 8 | 4 |
| 1g | 4-Cl | 4-Br | (S)-CH(CH3)2 | 8 | 4 | 4 | 4 | 16 | 8 | 8 | 8 |
| 1h | 4-Cl | 3,4-Cl | (S)-CH(CH3)2 | 2 | 1 | 1 | 1 | 4 | 1 | 4 | 2 |
| 1i | 4-Cl | 3,4-Cl | (S)-benzyl | 1 | 1 | 0.5 | 0.5 | 8 | 1 | 8 | 1 |
|
| |||||||||||
| AMP | — | — | — | >16 | >16 | >16 | 0.25 | >16 | >16 | >16 | 0.25 |
| CPX | — | — | — | >16 | >16 | >16 | 0.5 | >16 | >16 | >16 | 0.5 |
| VAN | — | — | — | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 |